Aaron Diamond AIDS Research Center, often abbreviated asADARC, is a United States medical research institution dedicated to finding a cure forHIV/AIDS. It is headed by scientist Dr.David Ho, who was the 1996Time magazine Person of the Year, and is located inNew York City.[1]
Opening in 1991, the center was the brainchild of theAaron Diamond Foundation headed by his widowIrene Diamond, theNew York City Department of Health, thePublic Health Research Institute andNew York University School of Medicine. It became affiliated withRockefeller University in 1996, and became part of Columbia University's medical school,Columbia University Vagelos College of Physicians and Surgeons, in 2019.[2][3]
One is the introduction ofcombinationantiretroviral therapy[4] to combatHIV drug resistance[4][5] and hence prevent[6]progression to fatal full-blown AIDS. David Ho and his team presented their remarkable clinical trial results at theInternational AIDS Conference 1996.[7] This marked a turning point in which HIV infection was no longer an absoluteterminal disease but a manageablechronic disease.[8]
... zidovudine was shown in 1990 to slow the clinical progression to AIDS in infected but asymptomatic subjects. However, a follow-up of those subjects found no evidence of longer survival with the use ofzidovudine...
... it's inevitable for HIV to develop drug resistance if you give it one drug at a time...
... We came to the conclusion that it's inevitable for HIV to develop drug resistance if you give it one drug at a time...
... if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult or statistically improbable for HIV to become resistant to all the drugs simultaneously.
... However, if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult...for HIV to become resistant to all the drugs simultaneously.
International AIDS Conference 1996 in Vancouver showing combination therapy results
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