Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Renin receptor

From Wikipedia, the free encyclopedia
(Redirected fromATP6AP2)
Protein-coding gene in the species Homo sapiens
ATP6AP2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3LBS,3LC8

Identifiers
AliasesATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R
External IDsOMIM:300556;MGI:1917745;HomoloGene:38097;GeneCards:ATP6AP2;OMA:ATP6AP2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ATP6AP2
Genomic location for ATP6AP2
BandXp11.4Start40,579,372bp[1]
End40,606,848bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for ATP6AP2
Genomic location for ATP6AP2
BandX|X A1.1Start12,454,040bp[2]
End12,483,288bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • visceral pleura

  • tibia

  • germinal epithelium

  • parietal pleura

  • epithelium of nasopharynx

  • retinal pigment epithelium

  • mucosa of paranasal sinus

  • orbitofrontal cortex

  • lateral nuclear group of thalamus

  • renal medulla
Top expressed in
  • Epithelium of choroid plexus

  • Paneth cell

  • ciliary body

  • iris

  • retinal pigment epithelium

  • conjunctival fornix

  • substantia nigra

  • medial dorsal nucleus

  • medial geniculate nucleus

  • aortic valve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10159

70495

Ensembl

ENSG00000182220

ENSMUSG00000031007

UniProt

O75787

Q9CYN9

RefSeq (mRNA)

NM_005765

NM_027439

RefSeq (protein)

NP_005756

NP_081715

Location (UCSC)Chr X: 40.58 – 40.61 MbChr X: 12.45 – 12.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Therenin receptor also known asATPase H(+)-transporting lysosomal accessory protein 2, or theprorenin receptor, is aprotein that in humans is encoded by theATP6AP2gene.[5][6][7]

Function

[edit]

The renin receptor bindsrenin andprorenin. Binding of renin to this receptor induces the conversion ofangiotensinogen toangiotensin I.[8]

This protein is associated withproton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000182220 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000031007 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998)."Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules".J Biol Chem.273 (18):10939–47.doi:10.1074/jbc.273.18.10939.PMID 9556572.
  6. ^Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)".Mol Vis.7:234–9.PMID 11590366.
  7. ^ab"Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
  8. ^Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002)."Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin".J. Clin. Invest.109 (11):1417–27.doi:10.1172/JCI14276.PMC 150992.PMID 12045255.

Further reading

[edit]

External links

[edit]


Stub icon

This article on agene on the humanX chromosome and/or its associatedprotein is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Renin_receptor&oldid=1301025677"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp