Plasma membrane calcium-transporting ATPase 4 is anenzyme that in humans is encoded by theATP2B4gene.[5][6]
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased byalternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (April 1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23".Genomics.9 (4):629–41.doi:10.1016/0888-7543(91)90356-J.PMID1674727.
Møller JV, Juul B, le Maire M (May 1996). "Structural organization, ion transport, and energy transduction of P-type ATPases".Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes.1286 (1):1–51.doi:10.1016/0304-4157(95)00017-8.PMID8634322.
Strehler EE, Zacharias DA (January 2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps".Physiological Reviews.81 (1):21–50.doi:10.1152/physrev.2001.81.1.21.PMID11152753.S2CID9062253.
Strehler EE, Treiman M (May 2004). "Calcium pumps of plasma membrane and cell interior".Current Molecular Medicine.4 (3):323–35.doi:10.2174/1566524043360735.PMID15101689.
Santiago-García J, Mas-Oliva J, Saavedra D, Zarain-Herzberg A (February 1996). "Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart".Molecular and Cellular Biochemistry.155 (2):173–82.doi:10.1007/BF00229314.PMID8700162.S2CID33539531.
Zacharias DA, DeMarco SJ, Strehler EE (April 1997). "mRNA expression of the four isoforms of the human plasma membrane Ca(2+)-ATPase in the human hippocampus".Brain Research. Molecular Brain Research.45 (1):173–6.doi:10.1016/S0169-328X(97)00009-0.PMID9105688.
