Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is anenzyme that inhumans is encoded by theATP2A3gene.[5][6]
This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in thesarcoplasmic orendoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed incardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation ofcalcium from thecytosol to the sarcoplasmic reticulumlumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[6]
ATP2A3 gene has been observed progressively downregulated inHuman papillomavirus-positiveneoplastic keratinocytes derived from uterine cervicalpreneoplastic lesions at different levels of malignancy.[7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervicalpreneoplastic lesions progression.[7]
^abRotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes".J Cell Physiol.230 (4):802–812.doi:10.1002/jcp.24808.hdl:11392/2066612.PMID25205602.S2CID24986454.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nat. Biotechnol.21 (5):566–9.doi:10.1038/nbt810.PMID12665801.S2CID23783563.
Chaâbane C, Corvazier E, Bredoux R, et al. (2006). "Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress".Biochem. Biophys. Res. Commun.345 (4):1377–85.doi:10.1016/j.bbrc.2006.05.054.PMID16725111.
Bredoux R, Corvazier E, Dally S, et al. (2006). "Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis".Platelets.17 (6):421–33.doi:10.1080/09537100600758719.PMID16973504.S2CID24473757.
