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ART26.12

From Wikipedia, the free encyclopedia

Pharmaceutical compound
ART26.12
Identifiers
  • (2R,4R)-3-(2,3-dihydro-1H-inden-2-yloxycarbonyl)-2,4-bis(2-methoxyphenyl)cyclobutane-1-carboxylic acid
CAS Number
PubChemCID
Chemical and physical data
FormulaC29H28O6
Molar mass472.537 g·mol−1
3D model (JSmol)
  • COC1=CC=CC=C1[C@@H]2C([C@H](C2C(=O)OC3CC4=CC=CC=C4C3)C5=CC=CC=C5OC)C(=O)O
  • InChI=1S/C29H28O6/c1-33-22-13-7-5-11-20(22)24-26(28(30)31)25(21-12-6-8-14-23(21)34-2)27(24)29(32)35-19-15-17-9-3-4-10-18(17)16-19/h3-14,19,24-27H,15-16H2,1-2H3,(H,30,31)/t24-,25-,26?,27?/m1/s1
  • Key:HFKXLDACQCGGEI-BINWOUKTSA-N

ART26.12 is an experimental drug that acts as a selective inhibitor of the enzymeFABP5, which usually breaks downendocannabinoids such asanandamide. ART26.12 thereby boosts endocannabinoid levels and hasanalgesic effects, showing efficacy against atypical pain syndromes such ashyperalgesia andallodynia. It is being researched as a potential treatment forneuropathy which can occur as a side effect of some kinds ofchemotherapy, as well as showing activity againstpsoriasis.[1][2][3][4]

References

[edit]
  1. ^Warren G, Osborn M, Tsantoulas C, David-Pereira A, Cohn D, Duffy P, et al. (July 2024)."Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy".The Journal of Pain.25 (7): 104470.doi:10.1016/j.jpain.2024.01.335.PMID 38232863.
  2. ^Warren WG, Osborn M, Duffy P, Yates A, O'Sullivan SE (October 2024)."Potential safety implications of fatty acid-binding protein inhibition".Toxicology and Applied Pharmacology.491 117079.Bibcode:2024ToxAP.49117079W.doi:10.1016/j.taap.2024.117079.PMID 39218163.
  3. ^Warren WG, Osborn M, David-Pereira A, Tsantoulas C, Xue W, Yates A, et al. (February 2025)."ART26.12, a novel fatty acid-binding protein 5 inhibitor, shows efficacy in multiple preclinical neuropathy models".European Journal of Pain.29 (2) e4718. London, England.doi:10.1002/ejp.4718.PMC 11671339.PMID 39188040.
  4. ^Warren WG, Osborn M, Yates A, O'Sullivan SE (April 2025). "ART26.12, a fatty acid-binding protein 5 inhibitor, shows efficacy in preclinical psoriasis models".The Journal of Investigative Dermatology.doi:10.1016/j.jid.2025.03.026.PMID 40210114.
Phytocannabinoids
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