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| Other names | ARM-390 |
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| Formula | C23H28N2O |
| Molar mass | 348.490 g·mol−1 |
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ARM-390 is anopioid-analgesic compoundselective for thedelta opioid receptor.[1][2][3]
It is an exceptionally selective, potent δopioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.[1]
In contrast to the delta-opioid selective agonistSNC-80, ARM390 was not found to produce receptordesensitization following multiple administrations. Although behavioral desensitization formed to the analgesic effect of ARM390 through a receptor internalization-independent mechanism,anxiolytic effects persisted during long-term treatment.[4] ARM390 has been dubbed a "low-internalizing agonist" of delta opioid receptors.[4]
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