ARID1A is a member of theSWI/SNF family, whose members have helicase andATPase activities and are thought to regulatetranscription of certain genes by altering thechromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodelling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The protein has two largeintrinsically disordered regions (IDRs) that mediate the interaction with binding partners.[8] It also possesses at least two conserved domains that are important for its function. First, it has anARID domain, which is aDNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SWI/SNF complex at thebeta-globin locus. Second, theC-terminus of the protein can stimulateglucocorticoid receptor-dependent transcriptional activation. The protein encoded by this gene confers specificity to the SWI/SNF complex and recruits the complex to its targets through either protein-DNA or protein-protein interactions.[9][10] Two transcript variants encoding differentisoforms have been found for this gene.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (June 1998). "Chromosomal mapping and expression of the human B120 gene".Gene.213 (1–2):189–193.doi:10.1016/S0378-1119(98)00194-2.PMID9630625.
^Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (December 1997). "Molecular cloning and expression of a novel human cDNA containing CAG repeats".Gene.204 (1–2):71–77.doi:10.1016/S0378-1119(97)00525-8.PMID9434167.
^Wang K, Kan J, Yuen ST, Shi ST, Chu KM, Law S, et al. (October 2011). "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer".Nature Genetics.43 (12):1219–1223.doi:10.1038/ng.982.PMID22037554.S2CID8884065.
Martens JA, Winston F (April 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes".Current Opinion in Genetics & Development.13 (2):136–142.doi:10.1016/S0959-437X(03)00022-4.PMID12672490.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–174.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–156.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Kozmik Z, Machon O, Králová J, Kreslová J, Paces J, Vlcek C (April 2001). "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex".Genomics.73 (2):140–148.doi:10.1006/geno.2001.6477.PMID11318604.
Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription".Nature.414 (6866):924–928.doi:10.1038/414924a.PMID11780067.S2CID4391100.
