 | |
| Names | |
|---|---|
| IUPAC name 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
|
| DrugBank |
|
| MeSH | AMPA |
| |
| |
| Properties | |
| C7H10N2O4 | |
| Molar mass | 186.167 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, better known asAMPA, is acompound that is a specificagonist for theAMPA receptor, where it mimics the effects of theneurotransmitterglutamate.[1]
There are several types of glutamatergic ion channels in the central nervous system including AMPA,kainic acid andN-methyl-D-aspartic acid (NMDA) channels. In thesynapse, these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.[2] AMPA generates fastexcitatory postsynaptic potentials (EPSP).[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have anequilibrium potential near 0 mV.
AMPA was first synthesized, along with several otheribotenic acid derivatives, byKrogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from aspartate sensitive receptors.[3]
