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| Formula | C20H19FINO |
| Molar mass | 435.281 g·mol−1 |
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AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is adesigner drug that acts as a potent and selectiveagonist for thecannabinoid receptorCB1. It is used in scientific research for mapping the distribution of CB1 receptors.[1]
AM-694 is anagonist forcannabinoid receptors. It has aKi of 0.08 nM atCB1 and 18 times selectivity overCB2 with aKi of 1.44 nM.[2] It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the18Fradiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.[1]
Pathways ofmetabolism includehydrolytic defluorination,carboxylation, andmonohydroxylation of theN-alkyl chain.[3][4]
AM-694 is scheduled in the "government decree on psychoactive substances banned from the consumer market".[5]
