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AM-0902

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Chemical compound

Pharmaceutical compound

AM-0902
Identifiers

IUPAC name 1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methylpurin-6-one
CAS Number	1883711-97-4^Y
PubChemCID	73297271
ChemSpider	58864849
UNII	3E4SQ96PCJ
ChEMBL	ChEMBL3785736
Chemical and physical data
Formula	C₁₇H₁₅ClN₆O₂
Molar mass	370.80 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl
InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 Key:AWJBWNUUODWOKQ-UHFFFAOYSA-N

AM-0902 is a drug which acts as a potent and selectiveantagonist for theTRPA1 receptor, and hasanalgesic andantiinflammatory effects.^[1]^[2]

^Schenkel LB, Olivieri PR, Boezio AA, Deak HL, Emkey R, Graceffa RF, et al. (March 2016). "Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity".Journal of Medicinal Chemistry.59 (6):2794–809.doi:10.1021/acs.jmedchem.6b00039.PMID 26942860.
^Huang Y, Chen SR, Chen H, Pan HL (May 2019)."Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain".Journal of Neurochemistry.149 (3):381–398.doi:10.1111/jnc.14677.PMC 6483867.PMID 30716174.

Activators

Blockers

Activators	Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P
Blockers	DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid

Activators	ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10 Eucalyptol (eucalyptus) Frescolat MGA Frescolat ML Geraniol Hydroxycitronellal Icilin Linalool Menthol (mint) PMD 38 Pregnenolone sulfate Rutamarin (Ruta graveolens) Steviol glycosides (e.g.,stevioside) (Stevia rebaudiana) Sweettastants (e.g.,glucose,fructose,sucrose; indirectly) Thio-BCTC WS-12
Blockers	AMG-333 Capsazepine Clotrimazole DCDPC Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5