Protein-coding gene in the species Homo sapiens
Aldehyde dehydrogenase 8 family, member A1 also known asALDH8A1 is anenzyme that in humans is encoded by theALDH8A1gene.[5]
This protein belongs to thealdehyde dehydrogenase family of enzymes. It was originally thought to play a role in a pathway of 9-cis-retinoic acidbiosynthesis in vivo. However, bioinformatics and experimental work has shown that it is more likely the aldehyde dehydrogenase of thekynurenine pathway, oxidizing 2-aminomuconate semialdehyde to 2-aminomuconic acid.[6] Two transcript variants encoding distinct isoforms have been identified for this gene.[7]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
