ALC-0159

Names
Other names 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
Identifiers
CAS Number	1849616-42-7
3D model (JSmol)	Interactive image
ChemSpider	112747193
UNII	PJH39UMU6H
InChI InChI=1S/C33H67NO3/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-34(33(35)32-37-31-30-36-3)29-27-25-23-21-19-17-15-13-11-9-7-5-2/h4-32H2,1-3H3 Key: BPWFJNQUTKVHIR-UHFFFAOYSA-N
SMILES CCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)C(=O)COCCOC
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

ALC-0159 is aPEG/lipid conjugate (i.e.PEGylated lipid), specifically, it is theN,N-dimyristylamide of2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule ofN,N-dimyristyl hydroxyacetamide). It is anon-ionic surfactant by its nature. It has been deployed in thePfizer-BioNTechSARS-CoV-2mRNA vaccine (0.05 mg per dose)^[1] that contains the active ingredienttozinameran.^[2]

Pfizer–BioNTech COVID-19 vaccinenanoparticle ingredients

• ALC-0315
• 1,2-distearoyl-sn-glycero-3-phosphocholine
• Cholesterol

Others

• Polyethoxylated tallow amine

• Assessment report, Comirnaty, Common name: COVID-19 mRNA vaccine (nucleoside-modified); Procedure No. EMEA/H/C/005735/0000 - gives structural formula for the compound (p. 24)

Thispharmacology-related article is astub. You can help Wikipedia byexpanding it.

• v
• t
• e

• Lipids
• Pfizer
• Products introduced in 2020
• Biotechnology
• Glycol ethers
• Carboxamides
• Pharmacology stubs

• Chemicals without a PubChem CID
• Articles without InChI source
• Articles without EBI source
• Articles without KEGG source
• Articles containing unverified chemical infoboxes
• Articles with short description
• Short description matches Wikidata
• All stub articles