Gamma-adducin is aprotein that in humans is encoded by theADD3gene.[5][6]
Adducins areheteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly ofspectrin-actin network inerythrocytes and at sites ofcell-cell contact inepithelial tissues. While adducins alpha and gamma areubiquitously expressed, the expression of adducin beta is restricted to brain andhematopoietic tissues. Adducin, originally purified from humanerythrocytes, was found to be aheterodimer of adducins alpha and beta.Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model ofhypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains. Theamino-terminal region isprotease-resistant andglobular in shape, while thecarboxy-terminal region is protease-sensitive. The latter contains multiplephosphorylation sites forprotein kinase C, the binding site forcalmodulin, and is required for association withspectrin andactin. Alternativelyspliced adducin gamma transcripts encoding differentisoforms have been described. The functions of the different isoforms are not known.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katagiri T, Ozaki K, Fujiwara T, Shimizu F, Kawai A, Okuno S, Suzuki M, Nakamura Y, Takahashi E, Hirai Y (Dec 1996). "Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin".Cytogenet Cell Genet.74 (1–2):90–5.doi:10.1159/000134389.PMID8893809.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Citterio L, Azzani T, Duga S, Bianchi G (2000). "Genomic organization of the human gamma adducin gene".Biochem. Biophys. Res. Commun.266 (1):110–4.doi:10.1006/bbrc.1999.1769.PMID10581174.
