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ADB-FUBIATA

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
ADB-FUBIATA
Legal status
Legal status
Identifiers
  • (2S)-2-[[2-[1-[(4-fluorophenyl)methyl]indol-3-yl]acetyl]amino]-3,3-dimethylbutanamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H26FN3O2
Molar mass395.478 g·mol−1
3D model (JSmol)
  • CC(C)(C)[C@@H](C(=O)N)NC(=O)CC1=CN(C2=CC=CC=C21)CC3=CC=C(C=C3)F
  • InChI=1S/C23H26FN3O2/c1-23(2,3)21(22(25)29)26-20(28)12-16-14-27(19-7-5-4-6-18(16)19)13-15-8-10-17(24)11-9-15/h4-11,14,21H,12-13H2,1-3H3,(H2,25,29)(H,26,28)/t21-/m1/s1
  • Key:KHAUCCNSUMBFOT-OAQYLSRUSA-N

ADB-FUBIATA (AD-18,FUB-ACADB,ADB-FUBIACA) is asynthetic cannabinoid compound first identified in 2021. It is closely related in structure to the older compoundADB-FUBICA but with theamide linker group extended by the addition of amethylene bridge. It started to be sold as an ingredient in grey-market synthetic cannabis blends following the introduction of legislation in China which for the first time introducedgeneral controls on various classes of synthetic cannabinoids,[2] but did not encompass compounds where the linker group had been extended in this fashion. ADB-FUBIATA has many times lower affinity forcannabinoid receptors than ADB-FUBICA with an EC50 of only 635 nM at CB1, but retains full agonist activity at this target, while being practically inactive at CB2.[3][4]

Legality

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In the United States ADB-FUBIATA is unscheduled at the federal level as of May 22, 2023 but may be considered under thefederal analogue act if sold for human consumption. North Dakota has placed ADB-FUBIATA into Schedule I on 04/27/2023.[5]

See also

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References

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  1. ^Anvisa (2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-07-25).Archived from the original on 2023-08-27. Retrieved2023-08-27.
  2. ^"关于将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告" [Announcement on the inclusion of 18 substances including synthetic cannabinoids and fluamine in the "Additional Catalogue of Controlled Varieties of Non-medicinal Narcotics and Psychotropic Drugs"].Ministry of Public Security of the People's Republic of China (in Chinese). 12 May 2021.
  3. ^Deventer MH, Van Uytfanghe K, Vinckier IM, Reniero F, Guillou C, Stove CP (September 2022)."A new cannabinoid receptor 1 selective agonist evading the 2021 "China ban": ADB-FUBIATA".Drug Testing and Analysis.14 (9):1639–1644.doi:10.1002/dta.3285.hdl:1854/LU-01GQ757043ZZ4MNSKMZ52FAKJ1.PMID 35570246.S2CID 248812121.
  4. ^Pasin D, Nedahl M, Mollerup CB, Tortzen C, Reitzel LA, Dalsgaard PW (September 2022)."Identification of the synthetic cannabinoid-type new psychoactive substance, CH-PIACA, in seized material".Drug Testing and Analysis.14 (9):1645–1651.doi:10.1002/dta.3333.PMC 9544820.PMID 35687099.
  5. ^"AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency"(PDF).Sixty-eighth Legislative Assembly of North Dakota in Regular Session. 3 January 2023.
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