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ACP-105

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
ACP-105
Legal status
Legal status
Identifiers
  • 2-chloro-4-(3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl)-3-methylbenzonitrile
CAS Number
PubChemCID
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H19ClN2O
Molar mass290.79 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1Cl)C#N)N2C3CCC2CC(C3)(C)O
  • InChI=1S/C16H19ClN2O/c1-10-14(6-3-11(9-18)15(10)17)19-12-4-5-13(19)8-16(2,20)7-12/h3,6,12-13,20H,4-5,7-8H2,1-2H3
  • Key:OUEODVPKPRQETQ-UHFFFAOYSA-N

ACP-105 is a drug which acts as aselective androgen receptor modulator (SARM). It has been investigated for potential use in the treatment ofage-related cognitive decline.[1][2][3][4] The drug has been found to reduceanxiety-like behavior in amouse model ofAlzheimer's disease when administered alone, as well as enhancespatial memory when coadministered with theselectiveestrogen receptor βagonistAC-186.[3] ACP-105 is ananiline SARM and is related toAC-262536 andvosilasarm (RAD140).[5]

References

[edit]
  1. ^Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, et al. (November 2009). "Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators".Journal of Medicinal Chemistry.52 (22):7186–7191.doi:10.1021/jm901149c.PMID 19856921.
  2. ^Dayger C, Villasana L, Pfankuch T, Davis M, Raber J (March 2011)."Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice".Brain Research.1381:134–140.doi:10.1016/j.brainres.2010.12.088.PMC 3048897.PMID 21219889.
  3. ^abGeorge S, Petit GH, Gouras GK, Brundin P, Olsson R (December 2013)."Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease".ACS Chemical Neuroscience.4 (12):1537–1548.doi:10.1021/cn400133s.PMC 3867967.PMID 24020966.
  4. ^Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021)."Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes".Drug Testing and Analysis.14 (2):349–370.doi:10.1002/dta.3189.hdl:1854/LU-8740373.PMID 34714606.S2CID 240152623.
  5. ^Zhang X, Sui Z (February 2013). "Deciphering the selective androgen receptor modulators paradigm".Expert Opinion on Drug Discovery.8 (2):191–218.doi:10.1517/17460441.2013.741582.PMID 23231475.S2CID 2584722.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists


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