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ABT-670

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Chemical compound

Pharmaceutical compound

ABT-670
Identifiers

IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide
CAS Number	630119-43-6^N
PubChemCID	16094676
ChemSpider	17252978^Y
UNII	4L6071XH2J
ChEMBL	ChEMBL219182^Y
CompTox Dashboard(EPA)	DTXSID30212235
Chemical and physical data
Formula	C₁₉H₂₃N₃O₂
Molar mass	325.412 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C
InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)^Y Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

ABT-670 is a drug which acts as a potent, orally bioavailabledopamine agonist selective for theD₄ subtype, which was developed as a possible treatment forerectile dysfunction,^[1] although its current uses are limited to scientific research.^[2]

References

[edit]

^Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction".Journal of Medicinal Chemistry.49 (25):7450–65.doi:10.1021/jm060662k.PMID 17149874.
^Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection".Neuroscience Letters.465 (3):242–7.doi:10.1016/j.neulet.2009.08.078.PMID 19733217.S2CID 27767274.

Drugs forerectile dysfunction (G04BE) andpremature ejaculation

Erectile dysfunction

Prostaglandins (E)	Alprostadil (PGE1)
PDE5 inhibitors	Avanafil Lodenafil Mirodenafil Sildenafil Simmerafil Tadalafil Udenafil Vardenafil
Alpha blockers	Moxisylyte (thymoxamine) Phentolamine Rauwolscine Yohimbine
Dopamine agonists	Apomorphine
Melanocortin agonists	Bremelanotide Melanotan II PL-6983
Others	Afrodor (acecarbromal,quebracho,vitamin E) Papaverine Trazodone

Premature ejaculation

SRIs/SSRIs	Dapoxetine Off-label:Citalopram Clomipramine Escitalopram Fluoxetine Paroxetine Sertraline Tramadol Others:Kanna
Oxytocin antagonists	Cligosiban Epelsiban
Local anesthetics	Benzocaine Lidocaine Lidocaine/prilocaine

See also:Sexual dysfunction medications
List of investigational sexual dysfunction drugs

Dopamine receptor modulators

D₁-like

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dipropyldopamine (DPDA) Dopamine Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Lu AE04621 Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Lu AF28996 Nuciferine PF-06412562 PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Glovadalen Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390