The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]
Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (1997). "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines".Cancer Res.57 (16):3537–47.PMID9270026.
Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S, Kuwano M (1998). "Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport".Biochem. Biophys. Res. Commun.252 (1):103–10.doi:10.1006/bbrc.1998.9546.PMID9813153.
Fromm MF, Leake B, Roden DM, Wilkinson GR, Kim RB (1999). "Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants".Biochim. Biophys. Acta.1415 (2):369–74.doi:10.1016/S0005-2736(98)00233-8.PMID9889399.
Cole SP (1999). "Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins".J. Natl. Cancer Inst.91 (10):888–9.doi:10.1093/jnci/91.10.888.PMID10340910.
Takada T, Suzuki H, Sugiyama Y (2000). "Characterization of 5'-flanking region of human MRP3".Biochem. Biophys. Res. Commun.270 (3):728–32.doi:10.1006/bbrc.2000.2507.PMID10772892.
Tatebe S, Sinicrope FA, Kuo MT (2002). "Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells".Biochem. Biophys. Res. Commun.290 (5):1427–33.doi:10.1006/bbrc.2002.6367.PMID11820781.
Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF (2004). "Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver".Pharmacogenetics.14 (3):155–64.doi:10.1097/00008571-200403000-00003.PMID15167703.
