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AB-CHFUPYCA

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
AB-CHFUPYCA
Legal status
Legal status
Identifiers
  • N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H29FN4O2
Molar mass400.498 g·mol−1
3D model (JSmol)
  • O=C(NC(C(N)=O)C(C)C)C1=CC(C2=CC=C(F)C=C2)=NN1CC3CCCCC3
  • InChI=1S/C22H29FN4O2/c1-14(2)20(21(24)28)25-22(29)19-12-18(16-8-10-17(23)11-9-16)26-27(19)13-15-6-4-3-5-7-15/h8-12,14-15,20H,3-7,13H2,1-2H3,(H2,24,28)(H,25,29)
  • Key:NDYOOVJIZQTGHY-UHFFFAOYSA-N

AB-CHFUPYCA (alsoAB-CHMFUPPYCA)[1] is a compound that was first identified as a component ofsynthetic cannabis products in Japan in 2015.[2][3] The name "AB-CHFUPYCA" is an acronym of its systematic nameN-(1-Amino-3-methyl-1-oxoButan-2-yl)-1-(CycloHexylmethyl)-3-(4-FlUorophenyl)-1H-PYrazole-5-CarboxAmide. There are two known regioisomers of AB-CHFUPYCA: 3,5-AB-CHMFUPPYCA (pictured) and 5,3-AB-CHMFUPPYCA.[4] The article[1] refers to both 3,5-AB-CHMFUPPYCA and 5,3-AB-CHMFUPPYCA as AB-CHMFUPPYCA isomers, so AB-CHMFUPPYCA and AB-CHFUPYCA are not names for a unique chemical structure.

AB-CHFUPYCA contains some similar structural elements to other synthetic cannabinoids such as5F-AB-FUPPYCA,JWH-307,JWH-030,JWH-147,AB-PINACA. It may be considered an analog of the traditionalpyrazole cannabinoid receptor 1 antagonistrimonabant. The pharmacological properties of AB-CHFUPYCA have not been studied.

See also

[edit]

References

[edit]
  1. ^McLaughlin G, Morris N, Kavanagh PV, Power JD, Twamley B, O'Brien J, et al. (September 2016)."The synthesis and characterization of the 'research chemical' N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer"(PDF).Drug Testing and Analysis.8 (9):920–9.doi:10.1002/dta.1864.PMID 26360802.S2CID 6300462.
  2. ^Uchiyama N, Asakawa K, Kikura-Hanajiri R, Tsutsumi T, Hakamatsuka T (August 2015). "A new pyrazole-carboxamide type synthetic cannabinoid AB-CHFUPYCA [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide] identified in illegal products".Forensic Toxicology.33 (2):367–373.doi:10.1007/s11419-015-0283-8.S2CID 20718579.
  3. ^Franz F, Angerer V, Brandt SD, McLaughlin G, Kavanagh PV, Moosmann B, Auwärter V (February 2017)."In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability"(PDF).Drug Testing and Analysis.9 (2):311–316.doi:10.1002/dta.1950.PMID 26888282.S2CID 205762732.
  4. ^"5-fluoro-3,5-AB-PFUPPYCA". Cayman Chemical Company. Retrieved25 May 2017.
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