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A-41988

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
A-41988
Identifiers
  • 8-[5-(4-Fluorophenyl)pentan-2-yl]-5,5-dimethyl-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC28H32FNO2
Molar mass433.567 g·mol−1
3D model (JSmol)
  • c4cc(F)ccc4CCCC(C)c3cc(O)c1C=2CN(CC#C)CCC=2C(C)(C)Oc1c3
  • InChI=1S/C28H32FNO2/c1-5-14-30-15-13-24-23(18-30)27-25(31)16-21(17-26(27)32-28(24,3)4)19(2)7-6-8-20-9-11-22(29)12-10-20/h1,9-12,16-17,19,31H,6-8,13-15,18H2,2-4H3 checkY
  • Key:UIDOJGIFVOOMLY-UHFFFAOYSA-N checkY
  (verify)

A-41988 (BW29Y) is ananalgesic drug which acts as acannabinoidagonist. It was developed byAbbott Laboratories in the 1970s,[1][2] and researched for potential use in the treatment ofglaucoma,[3] but never commercialised.

See also

[edit]

References

[edit]
  1. ^Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, et al. (April 1976). "Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains".Journal of Medicinal Chemistry.19 (4):461–71.doi:10.1021/jm00226a003.PMID 817021.
  2. ^Guterman A, Somani P, Bachand RT (1979). "Phase-I evaluation of 5-5-dimethyl-10-hydroxy-8-[5-(4-fluorophenyl)-2-pentyl]-2-(2-propynyl-1, 2, 3, 4-tetrahydro-5h-[1] benzopyrano [3, 4-d] pyridine (a-41988)-novel benzopyran derivative".Clinical Pharmacology and Therapeutics.25: 227.
  3. ^Tiedeman JS, Shields MB, Weber PA, Crow JW, Cocchetto DM, Harris WA, Howes JF (March 1981). "Effect of synthetic cannabinoids on elevated intraocular pressure".Ophthalmology.88 (3):270–7.doi:10.1016/s0161-6420(81)35052-0.PMID 7015221.
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
Cannabiphorols
Cannabinols
Cannabitriols
Cannabivarins
Delta-3-tetrahydrocannabinols
Delta-4-tetrahydrocannabinols
Delta-7-tetrahydrocannabinols
Delta-8-tetrahydrocannabinols
Delta-9-tetrahydrocannabinols
Delta-10-Tetrahydrocannabinols
Delta-11-Tetrahydrocannabinols
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cannabinoid
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agonists /
neocannabinoids
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(dibenzopyrans)
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AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers
(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)


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