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| Routes of administration | Oral |
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| ECHA InfoCard | 100.001.446 |
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| Formula | C7H7ClN4O2 |
| Molar mass | 214.61 g·mol−1 |
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8-Chlorotheophylline, also known as1,3-dimethyl-8-chloroxanthine, is astimulantdrug of thexanthine chemical class, with physiological effects similar tocaffeine.[1] Its main use is in combination (salt) withdiphenhydramine in theantiemeticdimenhydrinate (Dramamine).Diphenhydramine reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help reduce that side effect.[2]
Despite being classified as a xanthine stimulant, 8-chlorotheophylline generally does not produce anyhyperlocomotion above control in mice and does not appear to cross theblood-brain barrier well.[citation needed]
The 8-chloro modification is not selected for pharmacological properties; instead, it was to raise the acidity of the xanthineamine group enough to form a co-salt with diphenhydramine.[2]
The drug is also sold in combination withpromethazine as a salt.[3]