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7-Methyl-α-ethyltryptamine

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(Redirected from7-Methyl-αET)
Chemical compound
Pharmaceutical compound
7-Methyl-α-ethyltryptamine
Identifiers
  • 1-(7-methyl-1H-indol-3-yl)butan-2-amine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H18N2
Molar mass202.301 g·mol−1
3D model (JSmol)
  • CCC(N)CC1=CNC2=C(C)C=CC=C21
  • InChI=1S/C13H18N2/c1-3-11(14)7-10-8-15-13-9(2)5-4-6-12(10)13/h4-6,8,11,15H,3,7,14H2,1-2H3
  • Key:NBLFITFQOPGXLS-UHFFFAOYSA-N

7-Methyl-α-ethyltryptamine (7-Me-αET) is atryptamine derivative related toα-ethyltryptamine (αET). It was discovered by a team atUpjohn in the early 1960s.[1] It has similar pharmacological effects to αET, but is both 3-4 times more potent as aserotonin releasing agent, and 10 times more potent as amonoamine oxidase inhibitor,[2][3] making it potentially hazardous as this pharmacological profile is shared with drugs such asPMA and4-MTA, which are known to be dangerous in humans when used at high doses.

Chemistry

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Analogues

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Analogues of 7-methyl-AET includeα-ethyltryptamine (AET),4-methyl-AET,5-fluoro-AET,5-chloro-AET,7-chloro-AMT, and7-methyl-DMT, among others.

See also

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References

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  1. ^U.S. patent 3,296,072
  2. ^Hester JB, Greig ME, Anthony WC, Heinzelman RV, Szmuszkovicz J (May 1964). "Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives".Journal of Medicinal Chemistry.7 (3):274–9.doi:10.1021/jm00333a006.PMID 14204959.
  3. ^Burningham RA, Arimura GK, Yunis AA (July 1966). "Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets".Proceedings of the Society for Experimental Biology and Medicine.122 (3):711–4.doi:10.3181/00379727-122-31233.PMID 5918937.S2CID 24949288.

External links

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5-HT1
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5-HT37
5-HT3
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Tryptamines
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N-Acetyltryptamines
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