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60S ribosomal protein L37

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From Wikipedia, the free encyclopedia

Protein found in humans

RPL37

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4UG0,4V6X,5AJ0,4D67,4UJC,4D5Y,4UJE,4UJD,4V5Z

Identifiers

Aliases

RPL37, L37, ribosomal protein L37

External IDs

OMIM:604181;MGI:1914531;HomoloGene:68110;GeneCards:RPL37;OMA:RPL37 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5p13.1	Start	40,825,262bp^[1]
Band	5p13.1	End	40,835,222bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 A1	Start	5,146,127bp^[2]
Band	15\|15 A1	End	5,148,622bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

germinal epithelium

nipple

urethra

human penis

parietal pleura

pylorus

palpebral conjunctiva

caput epididymis

mucosa of sigmoid colon

visceral pleura

Top expressed in

embryo

embryo

ventricular zone

dentate gyrus of hippocampal formation granule cell

yolk sac

primary visual cortex

superior frontal gyrus

granulocyte

muscle of thigh

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	metal ion binding rRNA binding structural constituent of ribosome RNA binding
Cellular component	ribosome cytosol intracellular anatomical structure cytosolic large ribosomal subunit synapse
Biological process	SRP-dependent cotranslational protein targeting to membrane viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


6167


67281

Ensembl


ENSG00000145592


ENSMUSG00000041841

UniProt


P61927


Q9D823

RefSeq (mRNA)


NM_000997


NM_026069

RefSeq (protein)


NP_000988


NP_080345

Location (UCSC)

Chr 5: 40.83 – 40.84 Mb

Chr 15: 5.15 – 5.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

60S ribosomal protein L37 is aprotein that in humans is encoded by theRPL37gene.^[5]^[6]^[7]

Ribosomes, theorganelles that catalyzeprotein synthesis, consist of a small40S subunit and a large60S subunit. Together these subunits are composed of 4RNA species and approximately 80 structurally distinct proteins. This gene encodes aribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in thecytoplasm. The protein contains a C2C2-typezinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000145592 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000041841 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Barnard GF, Staniunas RJ, Puder M, Steele GD Jr, Chen LB (Sep 1994). "Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain".Biochim Biophys Acta.1218 (3):425–8.doi:10.1016/0167-4781(94)90197-x.PMID 7545944.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998)."A map of 75 human ribosomal protein genes".Genome Res.8 (5):509–23.doi:10.1101/gr.8.5.509.PMID 9582194.
^^a ^b"Entrez Gene: RPL37 ribosomal protein L37".

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:P61927 (Human 60S ribosomal protein L37) at thePDBe-KB.

Protein biosynthesis:translation (bacterial,archaeal,eukaryotic)

Proteins

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X,RPS4Y1,RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA /ribosome subunits

Archaea
(70S)

Large (50S):

Small (30S):

Bacteria
(70S)

Large (50S):

Small (30S):

Eukaryotes

Cytoplasmic (80S)	Large (60S): 5S 5.8S 28S Small (40S): 18S
Mitochondrial (55S)	Large (28S): MT-RNR2, 16S MT-tRNA^Val Small (39S): MT-RNR1, 12S
Chloroplast (70S)	Large (50S): 5S 4.5S 23S Small (30S): 16S

Ribosomal proteins

(See article table)

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