Ribosomes, theorganelles that catalyzeprotein synthesis, consist of a small40S subunit and a large60S subunit. Together, these subunits are composed of 4RNA species and approximately 80 structurally distinct proteins. This gene encodes aribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in thecytoplasm. In vitro, studies have shown that the chicken protein can bind toc-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for aWilms tumorsuppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternativepolyA signals exist. The variant with the longest 3' UTR overlaps thedeoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with thesmall nucleolar RNA geneU70, which is located in its fifthintron. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome.[6]
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