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6-MAPBT

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Pharmaceutical compound
6-MAPBT
Clinical data
Other names6-(2-(Methylamino)propyl)-1-benzothiophene; MY300; MY-300
Drug classMonoamine releasing agent;Serotonin5-HT1B receptoragonist;Entactogen
ATC code
  • None
Identifiers
  • 1-(1-benzothiophen-6-yl)-N-methylpropan-2-amine
PubChemCID
Chemical and physical data
FormulaC12H15NS
Molar mass205.32 g·mol−1
3D model (JSmol)
  • CC(CC1=CC2=C(C=C1)C=CS2)NC
  • InChI=1S/C12H15NS/c1-9(13-2)7-10-3-4-11-5-6-14-12(11)8-10/h3-6,8-9,13H,7H2,1-2H3
  • Key:ZTCVZGKXXWDMJJ-UHFFFAOYSA-N

6-MAPBT, also known as6-(2-(methylamino)propyl)-1-benzothiophene, is a possibleentactogen of thephenethylamine,amphetamine, andbenzothiophene families related toMDMA.[1][2][3]

It acts as amonoamine releasing agent andserotonin receptor modulator.[3] The drug'sEC50Tooltip half-maximal effective concentration values formonoamine release are 57 nM forserotonin and 71 nM fordopamine.[3] It is also apotentagonist of theserotonin5-HT1B receptor, with anEC50 of 24 nM, and is a potentantagonist of the serotonin5-HT2B receptor, with anIC50Tooltip half-maximal inhibitory concentration of 72 nM.[3] Conversely, it is far weaker as an agonist of the serotonin5-HT2A receptor (EC50 = 959 nM) and is inactive at the serotonin5-HT1A receptor.[3] In addition to the preceding actions, the drug is amonoamine oxidase A (MAO-A)inhibitor, with anIC50 of 945 nM.[3]

It producesanxiolytic-like andantiobsessional-like effects in themarble burying test in rodents.[3] However, benzothiophenes like 6-MAPBT, despite their induction of dopamine release, are said to lackhyperlocomotion orstimulant-like effects in rodents.[2][4]

6-MAPBT has been studied andpatented byMatthew J. Baggott atTactogen.[1][3] The drug has also been patented byMydecine and given the developmental code nameMY300.[5]

See also

[edit]

References

[edit]
  1. ^abHalford B (16 June 2025)."Drug companies are investing big in psychedelics, but can they engineer out the trip?".Chemical & Engineering News.100 (9): 28. Retrieved1 November 2025.What Tactogen is trying to do, Baggott says, is make novel molecules that share MDMA's core therapeutic effects but have fewer undesirable effects, such as acute hypertension, overuse liability, and decreased therapeutic effects with repeated use. "We're trying to make molecules that engineer away some of those things," he says. To accomplish that, Tactogen scientists use machine learning to model how changes to MDMA's structure might affect the drug's biochemistry. They synthesize the molecules that seem most interesting, such as 5-MAPBT and 6-MAPBT, test them in assays, and then feed that information back into their machine learning system.
  2. ^abMoosmann B, Niendorf LM (7 October 2022)."Analytica 2022 conference report on toxicological and forensic chemistry".Lab Automation News.Using (2-aminopropyl)benzo[b]thiophene analogs (APBTs) as a representative example and moving from synthesis to pharmacological evaluation Prof. Brandt discussed that the differentiation between various NPS isomers can be a challenge. APBT isomers, e.g., 5-MAPBT, 6-MAPBT, and many others are new monoamine transporter ligands that are similar to MDMA in both its structure and effects and bind to the 5-HT2A receptor subtype. He pointed out that despite having shown activity in vitro, they interestingly, and above all unexpectedly, lack stimulant effects as APBT isomers failed to trigger locomotor activity in mice. This suggests psychedelic and entactogenic effects combined with a low abuse potential, which, in turn, could be used as a therapeutic approach in drug-assisted psychotherapy and is worth investigating further.
  3. ^abcdefghWO 2022010937A1, Baggott M, "Advantageous benzothiophene compositions for mental disorders or enhancement", published 13 January 2022, assigned to Tactogen Inc. 
  4. ^Rudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, et al. (March 2022)."(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice".Neuropsychopharmacology.47 (4):914–923.doi:10.1038/s41386-021-01221-0.PMC 8882185.PMID 34750565.
  5. ^US 20240197679, Hoyer DW, Roscow RF, Ling R, Gao C, "Novel short-acting psychoactive compounds of the MDMA class", published 20 June 2024, assigned to Mydecine Innovations Group Inc. 

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