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6-Chloro-2-aminotetralin (6-CAT) is adrug which acts as aselective serotonin releasing agent (SSRA) and is a putativeentactogen in humans.[1][2] It is a rigidanalogue ofpara-chloroamphetamine (PCA).[1]
According to Nicholset al.,[3] 6-CAT is a non-neurotoxic analog ofPCA.
Other related compounds that are creditworthy of mention include6,7-DCAT[4] & 5,6-DCAT [57915-89-6].[4] These compounds were invented byBryan Molloy (the inventor ofProzac). These can be thought to be rigid analogs of3,4-Dichloroamphetamine and might be predicted to be similarly non-neurotoxic. Apositional isomer of the aforementioned two compounds is also known to exist in the literature with a 5,8-dichloro substitution pattern (PC9954388).[5] The compound depicted in the latter case is with thespirodecanone pharmacophore.
