 | |
| Names | |
|---|---|
| IUPAC name N-[17-(Cyclopropylmethyl)-3,14-dihydroxy-1′H-4,5α-epoxyindolo[2′,3′:6,7]morphinan-6′-yl]guanidine | |
| Systematic IUPAC name N-[(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
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| |
| Properties | |
| C27H29N5O3 | |
| Molar mass | 471.561 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
6′-Guanidinonaltrindole (6′-GNTI) is aκ–δ-opioid receptor selective ligand used in scientific research.[1]
With 6′-GNTI, evidence was provided for the first time thatreceptor oligomerization plays functional role in living organisms.[2]
6′-GNTI is an extremelybiased agonist of the κ-opioid receptor.[1] It is a potentpartial agonist of theG protein pathway but does not recruit theβ-arrestin pathway.[1] Due to itsfunctional selectivity for the G protein pathway, 6′-GNTI functions as anantagonist of nonbiased KOR agonists on the β-arrestin pathway.[1] It is thought that 6′-GTNI may be able to produceanalgesia withoutdysphoria and with a lower incidence oftolerance.[1]
