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5F-CUMYL-PEGACLONE

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
5F-CUMYL-PEGACLONE
Legal status
Legal status
Identifiers
  • 2,5-Dihydro-2-(1-methyl-1-phenylethyl)-5-(5-fluoropentyl)-1H-pyrido[4,3-b]indol-1-one
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC25H27FN2O
Molar mass390.502 g·mol−1
3D model (JSmol)
  • CC(C)(c1ccccc1)N4C=Cc3n(CCCCCF)c2ccccc2c3C4=O
  • InChI=1S/C25H27FN2O/c1-25(2,19-11-5-3-6-12-19)28-18-15-22-23(24(28)29)20-13-7-8-14-21(20)27(22)17-10-4-9-16-26/h3,5-8,11-15,18H,4,9-10,16-17H2,1-2H3
  • Key:SMRRORRDOWXERZ-UHFFFAOYSA-N

5F-CUMYL-PEGACLONE (5F-SGT-151,SGT-269) is agamma-carboline basedsynthetic cannabinoid that has been sold as adesigner drug, first being identified in Germany in 2017. It acts as a potent full agonist of the CB1 receptor.[1][2] It appears to be more toxic than related compounds such asCUMYL-PEGACLONE, and has been linked to numerous serious adverse reactions, some fatal.[3]

See also

[edit]

References

[edit]
  1. ^Mogler L, Halter S, Wilde M, Franz F, Auwärter V (2019)."Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE".Forensic Toxicology.37 (1):154–163.doi:10.1007/s11419-018-0447-4.PMC 6315001.PMID 30636984.
  2. ^Janssens L, Cannaert A, Connolly MJ, Liu H, Stove CP (June 2020)."In vitro activity profiling of Cumyl-PEGACLONE variants at the CB1 receptor: Fluorination versus isomer exploration".Drug Testing and Analysis.12 (9):1336–1343.doi:10.1002/dta.2870.hdl:1854/LU-8687072.PMID 32490586.S2CID 219285656.
  3. ^Giorgetti A, Mogler L, Halter S, Haschimi B, Alt A, Rentsch D, Schmidt B, Thoma V, Vogt S, Auwärter V (2019)."Four cases of death involving the novel synthetic cannabinoid 5F-Cumyl-PEGACLONE".Forensic Toxicology.38 (2):314–326.doi:10.1007/s11419-019-00514-w.hdl:11585/878663.S2CID 209449526.
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Receptor/signaling modulators
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