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| Formula | C20H26F2N4O2 |
| Molar mass | 392.451 g·mol−1 |
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5F-AB-FUPPYCA (also known asAZ-037) is apyrazole-basedsynthetic cannabinoid that is presumed to be anagonist of theCB1 receptor and has been sold online as adesigner drug.[2][3] It was first detected by theEMCDDA as part of a seizure of 540 g white powder in France in February 2015.[4]
The name AZ-037 is also used as a synonym for its structural isomer 5-fluoro-3,5-AB-PFUPPYCA.[5] Thus AZ-037 is being used as a synonym for two different compounds.
5-fluoro-3,5-AB-PFUPPYCA has been detected in synthetic cannabinoid smoke blends in the US as early as December 30, 2021, along with ADB-BUTINACA,MDA-19 (BZO-HEXOXIZID) andMDMB-4en-PINACA.[6]
5-fluoro-AB-PFUPPYCA contains some similar structural elements to other synthetic cannabinoids such asAB-CHFUPYCA,JWH-307,JWH-030,JWH-147,AB-PINACA. It may be considered an analog of the traditionalpyrazole cannabinoid receptor 1 antagonistrimonabant. The pharmacological properties of 5F-AB-FUPPYCA have not been studied.
In the United States, 5F-AB-FUPPYCA is unscheduled at the federal level as of May 22, 2023. It's possible that it may be considered under thefederal analogue act as a functional analog due to pharmacology or as a distant structural analog ofJWH-307.
North Dakota has placed 5F-AB-FUPPYCA (N-(1-carbamoyl-2-methyl-propyl)-2-(5-fluoropentyl)-5-(4-fluorophenyl)pyrazole-3-carboxamide) into Schedule I status on 04/27/2023. However, this did not include structural substitutions it gave to other cannabinoid structural classes. As such does not include other pyrazoles analogs such as the non-fluorinated AB-FUPPYCA analog.[7]
