Ribosomes, theorganelles thatcatalyzeprotein synthesis, consist of asmall 40S subunit and alarge 60S subunit. Together these subunits are composed of 4RNA species and approximately 80 structurally distinct proteins. This gene encodes aribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2zinc finger-like domain that can bind tozinc, can enhance thetumor suppressor activity ofRas-related protein 1A (KREV1). It is located in thecytoplasm. Variable expression of this gene incolorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome.[7]
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