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4-Phenylbutylamine

From Wikipedia, the free encyclopedia

Pharmaceutical compound
4-Phenylbutylamine
Clinical data
Other names
  • Benzenebutanamine
Identifiers
  • 4-phenylbutan-1-amine
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC10H15N
Molar mass149.237 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)CCCCN
4-Phenylbutylamine
Hazards
GHS labelling:[1]
GHS05: CorrosiveGHS07: Exclamation mark
Danger
H314,H315,H319,H335
P260,P264,P264+P265,P271,P280,P301+P330+P331,P302+P352,P302+P361+P354,P304+P340,P305+P351+P338,P305+P354+P338,P316,P319,P321,P332+P317,P337+P317,P362+P364,P363,P403+P233,P405,P501
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

4-Phenylbutylamine, also known asbenzenebutanamine, is aphenylalkylamine or phenylbutylamine, consisting of abenzene ring in which one of thehydrogen atoms is substituted by a 4-aminobutyl group. It is aprimary amine and a member of the benzene class oforganic compounds. It it penetrateslipid bilayers in the cubicliquid-crystalline phase.[2]

serine protease inhibitor, It has been used in research as a testinhibitor to study the function of theenzymetrypsin; it is capable ofmimicking the side chain of theamino acidlysine orarginine, which allows it to bind to the active site of the enzymetrypsin.[1][3][4]

References

[edit]
  1. ^abPubChem."Benzenebutanamine".pubchem.ncbi.nlm.nih.gov. Retrieved2026-02-02.
  2. ^Engström S, Nordén TP, Nyquist H (August 1999). "Cubic phases for studies of drug partition into lipid bilayers".European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences.8 (4):243–54.doi:10.1016/s0928-0987(99)00012-3.PMID 10425374.
  3. ^Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, et al. (April 2004)."Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements".Protein Science.13 (4):1056–1070.doi:10.1110/ps.03498604.PMC 2280040.PMID 15044735.
  4. ^"4-Phenylbutylamine".go.drugbank.com. Retrieved2026-02-02.
Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
(and further-extended)
Catecholamines
(and close relatives)
Cyclized
phenethylamines
Phenylalkylpyrrolidines
2-Benzylpiperidines
(phenidates)
Phenylmorpholines
(phenmetrazines)
Phenyloxazolamines
(aminorexes)
Isoquinolines and
tetrahydroisoquinolines
2-Aminoindanes
2-Aminotetralins
Others / unsorted
Related compounds
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