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| Formula | C15H14N2 |
| Molar mass | 222.291 g·mol−1 |
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4-NEMD is a potentsedative drug which acts as a selectivealpha-2 adrenergic receptoragonist. It is closely related todexmedetomidine but is several times more potent.[1] Like other alpha-2 agonists, it produces sedative andmuscle relaxant effects but without producingrespiratory depression. It is not currently used in medicine, but has been researched as the basis for a potential new generation of alpha-2 agonist drugs,[2][3] which may have selectivity for the different subtypes of the alpha-2 receptor.[4] It has two isomers, with the (S) isomer being the more potent, as withmedetomidine.[5] 4-NEMD was also investigated by the United States military as ananesthetic agent, most likely for use in surgery, but possibly also for use as a non-lethal incapacitating agent, although this has not been officially confirmed.[6]
