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4-Methyldiphenhydramine

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Chemical compound

Pharmaceutical compound

p-Methyldiphenhydramine
Identifiers

IUPAC name N,N-Dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number	19804-27-4
PubChemCID	19935
ChemSpider	18776^Y
UNII	P9633413CU
CompTox Dashboard(EPA)	DTXSID20903322
ECHA InfoCard	100.039.375
Chemical and physical data
Formula	C₁₈H₂₃NO
Molar mass	269.388 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O(CCN(C)C)C(c1ccccc1)c2ccc(cc2)C
InChI InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3^Y Key:PJUYQWIDNIAHIZ-UHFFFAOYSA-N^Y
(verify)

4-Methyldiphenhydramine is anantihistamine andanticholinergic.^[1]^[2]

^Rekker RF, Timmerman H, Harms AF, Nauta WT (May 1971). "The antihistaminic and anticholinergic activities of optically active diphenhydramine derivatives. The concept of complementarity".Arzneimittel-Forschung.21 (5):688–91.PMID 4398311.
^Rekker RF, Timmerman H, Nauta WT (1972). "Changes in antihistaminic and anticholinergic activities of diphenhydramine derivatives on quaternization and the role of an asymmetric centre".Chimica Therapeutica.7 (4):279–282.

mAChRsTooltip Muscarinic acetylcholine receptors

See also: Receptor/signaling modulators; Nicotinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

nAChRsTooltip Nicotinic acetylcholine receptors

Agonists
(and PAMsTooltip positive allosteric modulators)

Antagonists
(and NAMsTooltip negative allosteric modulators)

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

Agonists

Antagonists

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

Agonists	α-Methylhistamine BP 2.94 Cipralisant (GT-2331) GT-2203 (VUF-5296) Histamine Imetit Immepip Immethridine (BP-1-5375) L-Histidine Methimepip Proxyfan SCH-50971 VUF-5297
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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