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4-APBT

From Wikipedia, the free encyclopedia
Pharmaceutical compound
4-APBT
Clinical data
Other names4-(2-Aminopropyl)-1-benzothiophene
Drug classSerotonin–norepinephrine–dopamine releasing agent
Identifiers
  • 1-(1-benzothiophen-4-yl)propan-2-amine
Chemical and physical data
FormulaC11H13NS
Molar mass191.29 g·mol−1
3D model (JSmol)
  • CC(Cc1cccc2c1ccs2)N
  • InChI=1S/C11H13NS/c1-8(12)7-9-3-2-4-11-10(9)5-6-13-11/h2-6,8H,7,12H2,1H3
  • Key:NKOJSEHZOSSUEN-UHFFFAOYSA-N

4-APBT, also known as4-(2-aminopropyl)-1-benzothiophene, is amonoamine releasing agent (MRA) of theamphetamine andbenzothiophene families.[1][2] It acts specifically as a fairly well-balancedserotonin–norepinephrine–dopamine releasing agent (SNDRA), withEC50Tooltip half-maximal effective concentration values of 21.2 nM forserotonin, 46.2 nM fornorepinephrine, and 66.6 nM fordopamine in rat brainsynaptosomes.[2] 4-APBT was first described in thescientific literature by 2020.[1][2]

See also

[edit]

References

[edit]
  1. ^abBrandt SD, Carlino L, Kavanagh PV, Westphal F, Dreiseitel W, Dowling G, Baumann MH, Sitte HH, Halberstadt AL (August 2020)."Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants".Drug Test Anal.12 (8):1109–1125.doi:10.1002/dta.2813.PMC 8281332.PMID 32372465.
  2. ^abcRudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, Kavanagh PV, Dowling G, Holy M, Jaentsch K, Walther D, Brandt SD, Stockner T, Baumann MH, Halberstadt AL, Sitte HH (March 2022)."(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice".Neuropsychopharmacology.47 (4):914–923.doi:10.1038/s41386-021-01221-0.PMC 8882185.PMID 34750565.

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