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| Clinical data | |
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| Other names | 3-TME; 3-Ethylthio-4,5-dimethoxyphenethylamine; 4,5-Dimethoxy-3-ethylthiophenethylamine; 3-EtS-4-MeO-5-MeO-PEA |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Onset of action | "Quite early"[1] |
| Duration of action | 10–15 hours[1] |
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| Chemical and physical data | |
| Formula | C12H19NO2S |
| Molar mass | 241.35 g·mol−1 |
| 3D model (JSmol) | |
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3-Thiometaescaline (3-TME), also known as3-ethylthio-4,5-dimethoxyphenethylamine, is apsychedelic drug of thephenethylamine andscaline families related tomescaline.[1][2][3][4] It is theanalogue ofmetaescaline in which theethoxy group at the 3 position has been replaced with anethylthio group.[1][2][3][4] The drug is one of three possiblepositional isomers ofthiometaescaline (TME), the others being4-thiometaescaline (4-TME) and5-thiometaescaline (5-TME).[1][2][3][4]
In his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications,Alexander Shulgin lists 3-TME's dose as 60 to 100 mgorally and itsduration as 10 to 15 hours.[1][2][3] Itsonset is "quite early" and substantial effects occur by 1.5 hours.[1] The drug is approximately 4 to 6 times aspotent as mescaline.[2][3][4] The effects of 3-TME have been reported to includeintrospection andinsights,disinhibition, easyhumor,sleep disturbances, and increased psychological strength after the experience.[1] One person reported it as producing a "remarkable state" and another remarked that it was a kind of experience that should be had once a year if not more often.[1] Novisual or otherperceptual effects were mentioned.[1]
Thechemical synthesis of 3-TME has been described.[1][4]
3-TME was first described in thescientific literature byAlexander Shulgin andPeyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin inPiHKAL in 1991.[1]
