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| Clinical data | |
|---|---|
| Other names | 3-TM; 3-Methylthio-4,5-dimethoxyphenethylamine; 3,4-Dimethoxy-5-methylthiophenethylamine; 3-MeS-4-MeO-5-MeO-PEA |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
| ATC code |
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| Pharmacokinetic data | |
| Onset of action | ≤1 hour[1] |
| Duration of action | 8–12 hours[1] |
| Identifiers | |
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| CAS Number | |
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| ChEMBL | |
| Chemical and physical data | |
| Formula | C11H17NO2S |
| Molar mass | 227.32 g·mol−1 |
| 3D model (JSmol) | |
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3-Thiomescaline (3-TM), also known as3-methylthio-4,5-dimethoxyphenethylamine, is apsychedelic drug of thephenethylamine andscaline families related tomescaline (3,4,5-trimethoxyphenethylamine).[1][2][3][4] It is theanalogue of mescaline in which themethoxy group at the 3 position has been replaced with amethylthio group.[1][2][3][4] The drug is one of two possiblethiomescaline (TM)positional isomers, the other being4-thiomescaline (4-TM).[1][2][3][4]
In his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications,Alexander Shulgin lists 3-TM's dose as 60 to 100 mgorally and itsduration as 8 to 12 hours.[1][2][3][4] Itsonset is within 1 hour.[1] The drug has about 4 to 6 times thepotency of mescaline.[1][2][3][4] The effects of 3-TM have been reported to include color enhancement,closed-eyeimagery andfantasy, noopen-eye visuals,auditory–visualsynaesthesia withmusic,intoxication,relaxation, feelings of sublimity and peacefulness, conflicting energy, tension,paranoia,irritability, and guardedness.[1][4]
Thechemical synthesis of 3-TM has been described.[1][4]
3-TM was first described in the literature by Shulgin and colleagues by 1981.[4] Subsequently, it was described in greater detail by Shulgin inPiHKAL in 1991.[1]