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| Clinical data | |
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| Other names | 3-TE; 3-Methoxy-4-ethoxy-5-methylthiophenethylamine; 4-Ethoxy-3-methoxy-5-methylthiophenethylamine; 4-Ethoxy-5-methoxy-3-methylthiophenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Duration of action | 8–12 hours[1] |
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| Chemical and physical data | |
| Formula | C12H19NO2S |
| Molar mass | 241.35 g·mol−1 |
| 3D model (JSmol) | |
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3-Thioescaline (3-TE), also known as3-methoxy-4-ethoxy-5-methylthiophenethylamine, is apsychedelic drug of thephenethylamine andscaline families related tomescaline.[1][2][3][4] It is theanalogue ofescaline in which themethoxy group at the 3 position has been replaced with amethylthio group.[1][2][3][4] The drug is one of two possiblethioescaline (TE)positional isomers, the other being4-thioescaline (4-TE).[1][2][3][4]
In his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications,Alexander Shulgin lists 3-thioescaline's dose as 60 to 80 mgorally and itsduration as 8 to 12 hours.[1][2][3] The drug has approximately 5 or 6 times thepotency of mescaline.[2][3][4][1] The effects of 3-thioescaline have been reported to includeclosed-eyeimagery andfantasy, sounds having a deeperpitch,introspection, enhanced appreciation ofart andmusic,time dilation,body load, andsleep disturbances.[1] It was said to be psychedelic rather than just intoxicating.[1] The desired psychoactive effects were said to outweigh its physicalside effects.[1]
Thechemical synthesis of 3-thioescaline has been described.[1][4]
3-Thioescaline was first described in thescientific literature byAlexander Shulgin andPeyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin inPiHKAL in 1991.[1]
