Chemical compound
Pharmaceutical compound
3-Methoxyeticyclidine (3-MeO-PCE ), also known asmethoxieticyclidine ,[ 1] dissociative anesthetic that is qualitatively similar toPCE andPCP [ 1] designer drug .[ 2] [ 3] [ 4]
On October 18, 2012, theAdvisory Council on the Misuse of Drugs in theUnited Kingdom released a report aboutmethoxetamine , saying that the "harms of methoxetamine are commensurate withClass B of theMisuse of Drugs Act (1971) ", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of methoxetamine should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-MeO-PCE.[ 5]
This report also described the receptor binding profile of methoxetamine and three additional dissociatives3-MeO-PCP ,4-MeO-PCP , and 3-MeO-PCE, showing them to have significant affinity for the PCP site of theNMDA receptor (NMDAR) and was later published in more detail.[ 6]
3-MeO-PCE hasKi values of 61 nM for the NMDAR, 743 nM for thedopamine transporter , 2097 nM for thehistamine H2 receptor , 964 nM for thealpha-2A adrenergic receptor , 115 nM for theserotonin transporter , 4519 nM for theσ1 receptor , and 525 nM for theσ2 receptor .[ 6]
3-MeO-PCE is banned in Sweden[ 7] [ 8] [ 9]
As per Chile'sLey de drogas , aka Ley 20000,[ 10] ether of PCE, it is thus illegal.
^a b Morris H, Wallach J (July–August 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs".Drug Testing and Analysis .6 (7– 8):614– 32.doi :10.1002/dta.1620 .PMID 24678061 . ^ De Paoli G, Brandt SD, Wallach J, Archer RP, Pounder DJ (June 2013)."From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices" .Journal of Analytical Toxicology .37 (5):277– 83.doi :10.1093/jat/bkt023 PMID 23552616 . ^ Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, et al. (August 2016)."Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines" (PDF) .Drug Testing and Analysis .8 (8):801– 15.doi :10.1002/dta.1861 .PMID 26360516 .S2CID 1599386 . ^ "3-MeO-PCE" .New Synthetic Drugs Database . Archived fromthe original on 2016-07-29. Retrieved2016-08-27 .^ "Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine report, 2012" .UK Home Office . 18 October 2012.^a b Roth BL , Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L (March 2013)."The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor" .PLOS ONE .8 (3): e59334.Bibcode :2013PLoSO...859334R .doi :10.1371/journal.pone.0059334 PMC 3602154 PMID 23527166 .^ "Elva nya ämnen klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 28 June 2018.^ Riksdagsförvaltningen."Förordning (1992:1554) om kontroll av narkotika" .riksdagen.se (in Swedish). ^ "Verordnung des EDI vom 30. Mai 2011 über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (Betäubungsmittelverzeichnisverordnung, BetmVV-EDI)" (in German). Der Bundesrat.^ "SUSTITUYE LA LEY Nº 19.366, QUE SANCIONA EL TRAFICO ILICITO DE ESTUPEFACIENTES Y SUSTANCIAS SICOTROPICAS" (in Spanish). Bibloteca Del Congreso Nacional. 22 October 2015. Retrieved6 February 2018 .
Psychedelics (5-HT2A
Benzofurans Lyserg‐ Phenethyl‐
Piperazines Tryptamines
alpha -alkyltryptaminesx -DALT x -DET x -DiPT x -DMT 4,5-DHP-DMT 2,N,N-TMT 4-AcO-DMT 4-HO-5-MeO-DMT 4,N,N-TMT 4-Propionyloxy-DMT 5,6-diBr-DMT 5-AcO-DMT 5-Bromo-DMT 5-MeO-2,N ,N -TMT 5-MeO-4,N ,N -TMT 5-MeO-α,N,N-TMT 5-MeO-DMT 5-N ,N -TMT 7,N,N-TMT α,N,N-TMT (Bufotenin) 5-HO-DMT DMT Norbaeocystin (Psilocin) 4-HO-DMT (Psilocybin) 4-PO-DMT x -DPT Ibogaine-related x -MET x -MiPT Others
Others
Dissociatives (NMDAR antagonists )
Deliriants (mAChR antagonists ) Others
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