| 2021 MUSC Health Women's Open | ||||
|---|---|---|---|---|
| Date | 12–18 April | |||
| Edition | 49th | |||
| Category | WTA 250 | |||
| Draw | 32S / 16D | |||
| Prize money | US$235,238 | |||
| Surface | Green clay | |||
| Location | Charleston, South Carolina, United States | |||
| Venue | Family Circle Tennis Center | |||
| Champions | ||||
| Singles | ||||
 Astra Sharma | ||||
| Doubles | ||||
 Hailey Baptiste /Caty McNally | ||||
| ||||
The second2021Charleston Open (branded as theMUSC Health Women's Open for commercial reasons) was a tournament on the2021 WTA Tour. It was played on outdoorgreen clay courts inDaniel Island. It was held one day after the 48th edition ended and was a replacement tournament for other tournaments that were not held because of travel restrictions, and organised by Charleston Tennis with a single-year licence in 2021, held atFamily Circle Tennis Center from April 12 to 18, 2021.[1]
Astra Sharma def.
Ons Jabeur, 2–6, 7–5, 6–1Hailey Baptiste /Caty McNally def.Ellen Perez /Storm Sanders, 6–7(4–7), 6–4, [10–6]| Country | Player | Rank1 | Seed |
|---|---|---|---|
| TUN | Ons Jabeur | 28 | 1 |
 POL | Magda Linette | 51 | 2 |
| USA | Shelby Rogers | 52 | 3 |
 FRA | Alizé Cornet | 59 | 4 |
 JPN | Misaki Doi | 77 | 5 |
| AUS | Ajla Tomljanović | 78 | 6 |
| USA | Lauren Davis | 79 | 7 |
| USA | Madison Brengle | 81 | 8 |
The following players receivedwildcards into the main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Amanda Anisimova → replaced byCaty McNally
Irina-Camelia Begu → replaced by
Wang Yafan
Anna Blinkova → replaced byLiudmila SamsonovaDanielle Collins → replaced byFrancesca Di LorenzoCoco Gauff → replaced by
Viktoriya TomovaMadison Keys → replaced by
Sara Errani
Barbora Krejčíková → replaced byTereza MartincováAnn Li → replaced by
Danka KovinićJessica Pegula → replaced by
Clara Tauson
Rebecca Peterson → replaced byChristina McHale
Yulia Putintseva → replaced by
Renata ZarazúaAnastasia Potapova → replaced by
Stefanie Vögele
Laura Siegemund → replaced byKristie AhnSloane Stephens → replaced byNatalia Vikhlyantseva| Country | Player | Country | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| AUS | Ellen Perez | AUS | Storm Sanders | 117 | 1 |
| USA | Kaitlyn Christian | USA | Sabrina Santamaria | 123 | 2 |
| JPN | JPN | ||||
| AUS | Arina Rodionova |  NED | Rosalie van der Hoek | 167 | 4 |
The following pair received a wildcard into the doubles main draw:
The following pair received entry into the doubles main draw using a protected ranking:
The following pair received entry into the doubles main draw as an alternate:
Anna Blinkova /Lucie Hradecká → replaced byElixane Lechemia /Ingrid NeelMisaki Doi /Nao Hibino → replaced byLinda Fruhvirtová /Tereza MartincováCoco Gauff /Caty McNally → replaced by
Beatrice Gumulya /Jessy RompiesMakoto Ninomiya /Yang Zhaoxuan → replaced byJamie Loeb /
Erin Routliffe
