American college football season
The2021 Buffalo Bulls football team represented theUniversity at Buffalo as a member of theMid-American Conference (MAC) during the2021 NCAA Division I FBS football season. Led by first-year head coachMaurice Linguist, the Bulls compiled an overall record of 4–8 with a mark of 2–6 in conference play, tying for fourth place in the MAC's East Division. The team played home games atUniversity at Buffalo Stadium inAmherst, New York.
| Date | Time | Opponent | Site | TV | Result | Attendance |
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| September 2 | 7:00 p.m. | Wagner* | | ESPN3 | W 69–7 | 13,063 |
| September 11 | 3:30 p.m. | atNebraska* | | BTN | L 3–28 | 85,663 |
| September 18 | 12:00 p.m. | No. 16Coastal Carolina* | - University at Buffalo Stadium
- Buffalo, NY
| ESPN2 | L 25–28 | 16,739 |
| September 25 | 6:00 p.m. | atOld Dominion* | | ESPN+ | W 35–34 | 18,197 |
| October 2 | 12:00 p.m. | Western Michigan | - University at Buffalo Stadium
- Buffalo, NY
| CBSSN | L 17–24 | 17,344 |
| October 9 | 7:00 p.m. | atKent State | | ESPNU | L 38–48 | 12,105 |
| October 16 | 12:00 p.m. | Ohio | - University at Buffalo Stadium
- Buffalo, NY
| ESPN+ | W 27–26 | 12,909 |
| October 23 | 3:30 p.m. | atAkron | | ESPN+ | W 45–10 | 8,635 |
| October 30 | 12:00 p.m. | Bowling Green | - University at Buffalo Stadium
- Buffalo, NY
| CBSSN | L 44–56 | 13,163 |
| November 9 | 7:00 p.m. | atMiami (OH) | | ESPNU | L 18–45 | 10,069 |
| November 17 | 7:00 p.m. | Northern Illinois | - University at Buffalo Stadium
- Buffalo, NY
| ESPN2 | L 27–33OT | 13,097 |
| November 23 | 7:00 p.m. | atBall State | | ESPN+ | L 3–20 | 6,112 |
- *Non-conference game
Homecoming- Rankings fromAP Poll released prior to the game
- All times are inEastern time
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Defensive endMalcolm Koonce was selected in the third round of the2021 NFL draft by theLas Vegas Raiders.[4] Koonce was the 15th Buffalo player to be drafted in the program’s history, and the first since2017, when theCincinnati Bengals selected Bulls tight endMason Schreck in the seventh round, at No. 251.[5] Koonce became the third Buffalo player drafted by the Raiders, joiningTrevor Scott in2008 andKhalil Mack in2014.[5]
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