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2-Iodomelatonin

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
2-Iodomelatonin
Identifiers
  • N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H15IN2O2
Molar mass358.179 g·mol−1
3D model (JSmol)
  • CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)I
  • InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)
  • Key:FJDDSMSDZHURBJ-UHFFFAOYSA-N

2-Iodomelatonin is amelatonin analog used as aradiolabelled ligand for themelatonin receptors, MT1, MT2, and MT3. It acts as a full agonist at both MT1 and MT2 receptors.[1]

References

[edit]
  1. ^Audinot V, Mailliet F, Lahaye-Brasseur C, Bonnaud A, Le Gall A, Amossé C, Dromaint S, Rodriguez M, Nagel N, Galizzi JP, Malpaux B, Guillaumet G, Lesieur D, Lefoulon F, Renard P, Delagrange P, Boutin JA (June 2003). "New selective ligands of human cloned melatonin MT1 and MT2 receptors".Naunyn-Schmiedeberg's Arch Pharmacol.367 (6):553–61.doi:10.1007/s00210-003-0751-2.PMID 12764576.S2CID 20279702.
MT1Tooltip Melatonin receptor 1
MT2Tooltip Melatonin receptor 2
Unsorted
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds


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