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2-Fluoromethamphetamine

From Wikipedia, the free encyclopedia
Stimulant designer drug

Not to be confused with2-Fluoroamphetamine.

Pharmaceutical compound
2-Fluoromethamphetamine
Ball-and-stick model of the 2-fluoromethamphetamine molecule
Clinical data
Routes of
administration
By mouth
Drug classStimulant
Legal status
Legal status
Identifiers
  • (RS)-1-(2-Fluorophenyl)-N-methylpropan-2-amine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC10H14FN
Molar mass167.227 g·mol−1
3D model (JSmol)
  • CC(CC1=CC=CC=C1F)NC
  • InChI=1S/C10H14FN/c1-8(12-2)7-9-5-3-4-6-10(9)11/h3-6,8,12H,7H2,1-2H3 checkY
  • Key:XNWIKJYFOIDUGD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2-Fluoromethamphetamine (2-FMA) is astimulant drug of theamphetamine family which has been used as adesigner drug.[2][3][4] 2-FMA is commonly compared tolisdexamfetamine (Vyvanse), anddextroamphetamine due to its efficacy as a study or productivity aid.[citation needed] 2-FMA is purported to produce somewhat less euphoria than comparable amphetamines, likely due to its main mechanism of action consisting ofnorepinephrine reuptake inhibition.[5][failed verification]

Chemistry

[edit]

2-Fluoromethamphetamine is fluorinated analogue ofmethamphetamine, and is aregioisomer of3-FMA and4-FMA.

It does not activate the serotonin receptors, including5-HT2A,[5] unlike most stimulant drugs of the amphetamine family.

Legal status

[edit]

Canada

[edit]

As of 1996, 2-FMA is a controlled substance in Canada, due to being an analog ofmethamphetamine.[1]

China

[edit]

As of October 2015, 2-FMA is a controlled substance in China.[6]

Germany

[edit]

As of 13 December 2014, 2-FMA is a controlled substance in Germany.[7] It is controlled under Anlage I BtMG (Narcotics Act, Schedule I).[8] Substances controlled under Anlage I BtMG are illegal to manufacture, possess, import, export, buy, sell, procure or dispense without a license. Violations of the law are punishable by a fine or imprisonment for up to five years.[9]

Ukraine

[edit]

As of July 2019, 2-FMA is a controlled substance in Ukraine (considered a narcotic).[10]

United States

[edit]

As a close analog ofscheduledcontrolled substance,[2] sale orpossession of 2-FMA could be potentially be prosecuted under theFederal Analogue Act.[11]

See also

[edit]

References

[edit]
  1. ^abLegislative Services Branch (31 March 2022)."Consolidated federal laws of Canada, Controlled Drugs and Substances Act".laws-lois.justice.gc.ca.Archived from the original on 11 June 2022. Retrieved11 August 2022.
  2. ^abRösner P, Quednow B, Girreser U, Junge T (March 2005). "Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs)".Forensic Science International.148 (2–3):143–156.doi:10.1016/j.forsciint.2004.05.003.PMID 15639609.
  3. ^Camilleri A, Johnston MR, Brennan M, Davis S, Caldicott DG (April 2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone".Forensic Science International.197 (1–3):59–66.doi:10.1016/j.forsciint.2009.12.048.PMID 20074881.
  4. ^Ishii A, Sato K, Kusakabe K, Kato N, Wada T (February 2023). "Identification and Quantitative Analysis of 2-Fluoromethamphetamine and Its Metabolites in Human Urine".Journal of Analytical Toxicology.47 (1):59–65.doi:10.1093/jat/bkac026.PMID 35562170.
  5. ^abÅstrand A, Guerrieri D, Vikingsson S, Kronstrand R, Green H (December 2020)."In vitro characterization of new psychoactive substances at the μ-opioid, CB1, 5HT1A, and 5-HT2A receptors-On-target receptor potency and efficacy, and off-target effects".Forensic Science International.317 110553.doi:10.1016/j.forsciint.2020.110553.PMID 33160102.S2CID 226279968.
  6. ^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived fromthe original on 1 October 2015. Retrieved1 October 2015.
  7. ^Bundesgesetzblatt."Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften – Vom 5. Dezember 2014" (in German). Bundesanzeiger-Verlags-GmbH. Retrieved6 April 2022.
  8. ^Bundesministerium der Justiz."Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) Anlage I (zu § 1 Abs. 1) (nicht verkehrsfähige Betäubungsmittel)" (in German). Retrieved6 April 2022.
  9. ^Bundesministerium der Justiz."Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) § 29 Straftaten" (in German). Retrieved6 April 2022.
  10. ^"Про внесення змін до Закону України "Про обіг в Україні наркотичних засобів, психотропних речовин, їх аналогів і прекурсорів"" (in Ukrainian). Verkhovna Rada of Ukraine. 23 July 2019.Archived from the original on 5 September 2021. Retrieved6 September 2021.
  11. ^"Federal Controlled Substance Analogue Act Summary".Erowid Analog Law Vault.
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