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| Formula | C9H12FN |
| Molar mass | 153.200 g·mol−1 |
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2-Fluoroamphetamine (2-FA) is astimulant drug from theamphetamine family which has been sold as adesigner drug.[1] 2-Fluoroamphetamine differs from3-fluoroamphetamine and4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making thempositional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through theblood–brain barrier, as is desirable incentral nervous system pharmaceutical agents, is a common practice due to the corresponding increase inlipophilicity granted by this substitution.[2][3]
Anorexiant dose (amount inhibiting food intake by 50% for 2 hours, given 1 hour earlier) = 15 mg/kg (rat; p.o.).[4][medical citation needed]
Analgesic dose (50% inhibition of response to tail-clamp) = 20 mg/kg (mouse; i.p.).[4][medical citation needed]
Effect on blood pressure: 0.5 mg/kg (rat; i.v.) produces an increase in BP of 29 mm.[4][medical citation needed]
LD50 (mouse; i.p.) = 100 mg/kg.[4][medical citation needed]
TheFederal Analogue Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended (ref 1) for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act, if, as stated above, it is intended for human consumption.
As of October 2015 2-FA is a controlled substance in China.[5]
Scheduled in the "government decree on substances, preparations and plants considered to be narcotic drugs" and is hence illegal.[6]
