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| Other names | 2-AT; 1,2,3,4-Tetrahydronaphthalen-2-amine; THN |
| Routes of administration | Oral |
| Drug class | Norepinephrine–dopamine releasing agent;Stimulant |
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| ECHA InfoCard | 100.019.067 |
| Chemical and physical data | |
| Formula | C10H13N |
| Molar mass | 147.221 g·mol−1 |
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2-Aminotetralin (2-AT), also known as1,2,3,4-tetrahydronaphthalen-2-amine (THN), is astimulantdrug of the2-aminotetralin family with achemical structure consisting of atetralin core with anamine assubstituent.[1][2]
2-AT is a rigidanalogue ofphenylisobutylamine and fully substitutes ford-amphetamine in ratdrug discrimination tests, although at one-half to one-eighth thepotency.[1][3] It showed greater potency than a variety of other amphetamine homologues, including2-amino-1,2-dihydronapthalene (2-ADN),2-aminoindane (2-AI),1-naphthylaminopropane (1-NAP),2-naphthylaminopropane (2-NAP),1-phenylpiperazine (1-PP),6-ABTooltip 6-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene, and7-ABTooltip 7-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene.[3][1][4]
2-AT has been shown toinhibit thereuptake ofserotonin andnorepinephrine, and might induce theirrelease as well.[5][6] It is also likely to act ondopamine on account of its full substitution of d-amphetamine inrodent studies.[1][3]
A number ofderivatives of 2-aminotetralin exist, including:
In previous studies, 2-AT either did not stimulate spontaneous motor activity in mice (1,8), or it had 10% of the activity of amphetamine (24). Yet, in the present study, it mimicked (+)-amphetamine as a DS in rats, in agreement with the results of Glennon et al. (7). However, 2-AT was one-half as potent as (+)-amphetamine in that study but only one-eighth as potent as (+)-amphetamine in the present experiment.