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| Names | |
|---|---|
| Preferred IUPAC name 2-[(Diphenylboranyl)oxy]ethan-1-amine | |
| Other names 2-Aminoethyl diphenyl borate Diphenylborinic acid 2-aminoethyl ester 2-Aminoethyl diphenylborinate | |
| Identifiers | |
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3D model (JSmol) | |
| Abbreviations | 2-APB |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.007.607 |
| EC Number |
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| KEGG | |
| UNII | |
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| Properties | |
| C14H16BNO | |
| Molar mass | 225.10 g·mol−1 |
| Appearance | white |
| Density | 1.04g/cm3 |
| Melting point | 192 to 194 °C (378 to 381 °F; 465 to 467 K) |
| Boiling point | 325.3 °C (617.5 °F; 598.5 K) at 760mmHg |
| Hazards | |
| GHS labelling: | |
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| Warning | |
| H302,H315,H319,H335 | |
| P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P312,P321,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501 | |
| Flash point | 150.6 °C (303.1 °F; 423.8 K) |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit bothIP3 receptors[1] andTRP channels (although it activatesTRPV1,TRPV2, &TRPV3 at higher concentrations).[2][3] In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibitgap junctions made of connexin.[4] Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.[5][6][7]
