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2,3-Dimethylphenylpiperazine

From Wikipedia, the free encyclopedia
Pharmaceutical compound
2,3-Dimethylphenylpiperazine
Clinical data
Other names2,3-DMPP; 2,3-XP; PAL-218; PAL218
Drug classPartialserotonin–norepinephrine releasing agent
Identifiers
  • 1-(2,3-dimethylphenyl)piperazine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.012.540Edit this at Wikidata
Chemical and physical data
FormulaC12H18N2
Molar mass190.290 g·mol−1
3D model (JSmol)
  • CC1=C(C(=CC=C1)N2CCNCC2)C
  • InChI=1S/C12H18N2/c1-10-4-3-5-12(11(10)2)14-8-6-13-7-9-14/h3-5,13H,6-9H2,1-2H3
  • Key:LIKXJDINUMWKQA-UHFFFAOYSA-N

2,3-Dimethylphenylpiperazine (2,3-DMPP; code namePAL-218) is amonoamine releasing agent anddesigner drug of thephenylpiperazine family.[1][2][3][4] It acts as apartialserotonin–norepinephrine releasing agent (SNRA), withEC50Tooltip half-maximal effective concentration (EmaxTooltip maximal efficacy) values of 24 to 26 nM (85%) forserotonin, 13.7 to 56 nM (62%) fornorepinephrine, and 1,207 to 1,320 nM (66%) fordopamine (22–96-fold lower than serotonin and norepinephrine).[1][2] Its possible activities atserotonin receptors were not reported.[1][2] The drug was first described in thescientific literature by 2009.[3][1][2]

See also

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References

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  1. ^abcdRothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012)."Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters".J Pharmacol Exp Ther.341 (1):251–262.doi:10.1124/jpet.111.188946.PMC 3364510.PMID 22271821.
  2. ^abcdSeverinsen K, Kraft JF, Koldsø H, Vinberg KA, Rothman RB, Partilla JS, Wiborg O, Blough B, Schiøtt B, Sinning S (September 2012)."Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters".ACS Chem Neurosci.3 (9):693–705.doi:10.1021/cn300040f.PMC 3447394.PMID 23019496.
  3. ^abTakahashi M, Nagashima M, Suzuki J, Seto T, Yasuda I, Yoshida T (February 2009). "Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry".Talanta.77 (4):1245–1272.doi:10.1016/j.talanta.2008.07.062.PMID 19084633.
  4. ^"Analytical and Synthetic Studies on Designer Drugs of the Piperazine Class".Office of Justice Programs. 1 July 2014. Retrieved13 March 2025.

External links

[edit]
DRAsTooltip Dopamine releasing agents
NRAsTooltip Norepinephrine releasing agents
SRAsTooltip Serotonin releasing agents
Others


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