| Date | Opponent | Rank | Site | Result | Attendance | Source |
|---|
| September 1 | South Dakota* | | | W 24–15 | 8,000 | |
| September 8 | Butler* | | - O'Brien Stadium
- Charleston, IL
| W 38–0 | 7,500 | |
| September 15 | Wayne State (MI)* | | - O'Brien Stadium
- Charleston, IL
| W 58–21 | 7,500 | |
| September 22 | atNortheast Missouri State* | | | W 46–3 | 5,500 | |
| September 29 | atSouthern Illinois* | No. 1 | | W 22–14 | 17,769 | |
| October 6 | Western Illinois | No. 1 | - O'Brien Stadium
- Charleston, IL
| L 7–10 | 7,500 | |
| October 20 | atNorthern Michigan | No. 4 | | W 38–21 | 10,000 | |
| October 27 | atNorthern Iowa | No. 4 | | L 7–10 | 10,700–10,780 | [1] |
| November 3 | No. 2Youngstown State | No. 8 | - O'Brien Stadium
- Charleston, IL
| L 21–49 | 12,000 | |
| November 10 | atIllinois State* | | | W 24–0 | 10,272 | [2] |
| November 17 | Akron | | - O'Brien Stadium
- Charleston, IL
| L 16–27 | 6,500 | |
|