On July 25, 1822,William Hendricks (DR) ofIndiana's at-large district resigned to run forGovernor of Indiana. Hendricks had represented the state since it was first admitted to the Union.
| Candidate | Party | Votes[1] | Percent |
|---|---|---|---|
| Jonathan Jennings | Jacksonian Republican | 13,351 | 69.3% |
| Davis Floyd | Democratic-Republican | 5,971 | 30.6% |
Jennings had previously served asdelegate forIndiana Territory in the11th through14th Congresses. Jennings took his seat December 2[2]