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18-Methylaminocoronaridine

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Chemical compound

Pharmaceutical compound

18-Methylaminocoronaridine
Identifiers

CAS Number	1807784-35-5^N[EPA]
PubChemCID	71308131
ChemSpider	24721797^Y
CompTox Dashboard(EPA)	DTXSID301046165
Chemical and physical data
Formula	C₂₂H₂₉N₃O₂
Molar mass	367.493 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c4cccc1c4[nH]c3c1CCN2CC(C5)CC3(C(=O)OC)C2C5CCNC
InChI InChI=1S/C22H29N3O2/c1-23-9-7-15-11-14-12-22(21(26)27-2)19-17(8-10-25(13-14)20(15)22)16-5-3-4-6-18(16)24-19/h3-6,14-15,20,23-24H,7-13H2,1-2H3/t14-,15+,20+,22-/m1/s1^Y Key:YKMOJVPLIUXEIP-SVBQBFEESA-N^Y
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(−)-18-Methylaminocoronaridine (18-MAC) is a second generation synthetic derivative ofibogaine developed by the research team led by the pharmacologistStanley D. Glick from theAlbany Medical College and the chemistMartin E. Kuehne from theUniversity of Vermont.^[1]^[2]

^Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, et al. (June 2003). "Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents".Journal of Medicinal Chemistry.46 (13):2716–30.doi:10.1021/jm020562o.PMID 12801235.
^Pace CJ, Glick SD, Maisonneuve IM, He LW, Jokiel PA, Kuehne ME, Fleck MW (May 2004). "Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration".European Journal of Pharmacology.492 (2–3):159–67.doi:10.1016/j.ejphar.2004.03.062.PMID 15178360.