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| Other names | 11β-MNT; 11β-Methylestr-4-en-17β-ol-3-one |
| Routes of administration | By mouth |
| Drug class | Androgen;Anabolic steroid;Progestogen |
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| Chemical and physical data | |
| Formula | C19H28O2 |
| Molar mass | 288.431 g·mol−1 |
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11β-Methyl-19-nortestosterone (11β-MNT) is asynthetic andorally activeanabolic–androgenic steroid (AAS) and aderivative ofnandrolone (19-nortestosterone) which was developed by the Contraceptive Development Branch (CDB) of theNational Institute of Child Health and Human Development (NICHD) and has not been marketed at this time.[1][2][3]
The C17βdodecylcarbonateester of 11β-MNT,11β-methyl-19-nortestosterone 17β-dodecylcarbonate (11β-MNTDC) (CDB-4754), is aprodrug of 11β-MNT.[1][2][3] Along with the closely related AASdimethandrolone (7α,11β-dimethyl-19-nortestosterone; CDB-1321) and its ester prodrugdimethandrolone undecanoate (CDB-4521), 11β-MNT and 11β-MNTDC are under investigation as potentialmale contraceptives and to treat malehypogonadism.[1][2][3]
11β-MNT does not undergoaromatization into the correspondingestrogenicmetabolite 11β-methylestradiol, and for this reason, has no potential for estrogenicside effects such asgynecomastia.[2] In addition, unliketestosterone, 11β-MNT does not appear to undergo5α-reduction into the corresponding 5α-dihydrogenated metabolite 5α-dihydro-11β-MNT (5α-DHMNT).[3] This conclusion is based on the fact that 5α-DHMNT is 4 to 8 times aspotent as 11β-MNT in terms ofandrogenicity inanimalbioassays, yet the co-administration of the5α-reductase inhibitordutasteride with 11β-MNT had no influence on its potency in assays using tissues that express 5α-reductase like theventral prostate andseminal vesicles.[3] Due to lack of potentiation by 5α-reductase in androgenic tissues like theskin,hair follicles, and prostate gland, 11β-MNT may have a lower risk of certain side effects such asoily skin,acne,androgenic alopecia (pattern hair loss),prostate enlargement, andprostate cancer than testosterone and certain other AAS.[3]
Similarly to nandrolone, dimethandrolone, and other 19-nortestosterone derivatives, 11β-MNT has been found to possessprogestogenic activity.[4] Because of its dual activity as an AAS and progestogen, 11β-MNT may have greaterefficacy in suppression ofspermatogenesis and hencemale fertility than pure AAS like testosterone.[4]
Oral 11β-MNT has shown little to no potential forhepatotoxicity in animals, similarly to testosterone but unlike17α-alkylated AAS likemethyltestosterone.[5] The drug notably shows a much lower hepatotoxic potential than dimethandrolone and trestolone (7α-methyl-19-nortestosterone; MENT), which may have an increased risk due to their shared C7αmethyl group (although a risk that is still significantly lower than that of 17α-alkylated AAS).[5]
11β-MNT, or 11β-methyl-19-nortestosterone, also known as 11β-methylestr-4-en-17β-ol-3-one, is asyntheticestranesteroid and a non-17α-alkylatedderivative ofnandrolone (19-nortestosterone).[4]
