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OML-632

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(Redirected from1-Hydroxymethyl-LSD)

Pharmaceutical compound
OML-632
Clinical data
Other namesOML-632; OML632; 1-Hydroxymethyllysergic acid diethylamide; 1-Hydroxymethyl-d-lysergic acid diethylamide; 1-Oxy-methyl-LSD; 1-Oxymethyl-LSD; Oxymethyl-LSD
Routes of
administration
Oral
Drug classSerotonin receptor modulator;Serotonergic psychedelic;Hallucinogen
ATC code
  • None
Identifiers
  • (6aR,9R)-N,N-Diethyl-4-(hydroxymethyl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
Chemical and physical data
FormulaC21H27N3O2
Molar mass353.466 g·mol−1
3D model (JSmol)
  • CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3CO)CC
  • InChI=1S/C21H27N3O2/c1-4-23(5-2)21(26)15-9-17-16-7-6-8-18-20(16)14(12-24(18)13-25)10-19(17)22(3)11-15/h6-9,12,15,19,25H,4-5,10-11,13H2,1-3H3/t15-,19-/m1/s1
  • Key:MCNBQMJSTKRHKK-DNVCBOLYSA-N

OML-632, also known as1-hydroxymethyllysergic acid diethylamide (1-hydroxymethyl-LSD), is apsychedelic drug of thelysergamide family related tolysergic acid diethylamide (LSD).[1][2][3][4][5][6][7]

Interactions

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See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Pharmacology

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Pharmacodynamics

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OML-632 has about 66% of thehallucinogenicpotency of LSD in humans (which is stated as active at 50–100 μg) and about 59% of theantiserotonergic activity of LSD in the isolated ratuterusin vitro.[8][9][5][6][10][11] However, OML-632 may simply act as aprodrug of LSD.[6][11] It has also been said to serve as ametabolic intermediate in thedemethylation of1-methyl-LSD (MLD-41) into LSD.[11]

History

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OML-632 was first described in thescientific literature by 1957.[12][13][4][14] The compound has been mistakenly referred to as "1-methoxy-LSD" or "1-MeO-LSD" in some publications.[15][16][17]

See also

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References

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  1. ^Shulgin AT (1982)."Chemistry of Psychotomimetics". In Hoffmeister F, Stille G (eds.).Psychotropic Agents, Part III: Alcohol and Psychotomimetics, Psychotropic Effects of Central Acting Drugs. Handbook of Experimental Pharmacology. Vol. 55 / 3. Berlin: Springer Berlin Heidelberg. pp. 3–29.doi:10.1007/978-3-642-67770-0_1.ISBN 978-3-642-67772-4.OCLC 8130916.
  2. ^Shulgin AT (1976)."Psychotomimetic Agents". In Gordon M (ed.).Psychopharmacological Agents: Use, Misuse and Abuse. Medicinal Chemistry: A Series of Monographs. Vol. 4. Academic Press. pp. 59–146.doi:10.1016/b978-0-12-290559-9.50011-9.ISBN 978-0-12-290559-9.
  3. ^Shulgin AT (1980)."Hallucinogens". In Burger A, Wolf ME (eds.).Burger's Medicinal Chemistry. Vol. 3 (4 ed.). New York: Wiley. pp. 1109–1137.ISBN 978-0-471-01572-7.OCLC 219960627.
  4. ^abAbramson HA (1959). "Lysergic Acid Diethylamide (LSD-25): XXIX. The Response Index as a Measure of Threshold Activity of Psychotropic Drugs in Man".The Journal of Psychology.48 (1):65–78.doi:10.1080/00223980.1959.9916341.ISSN 0022-3980.
  5. ^abFanchamps A (1978)."Some Compounds With Hallucinogenic Activity". In Berde B, Schild HO (eds.).Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology (HEP). Vol. 49. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 567–614.doi:10.1007/978-3-642-66775-6_8.ISBN 978-3-642-66777-0. Archived fromthe original on 30 March 2025.Table 2. Psychotomimetic activity and some pharmacodynamic effects of structural analogues of LSD [...]
  6. ^abcMangner TJ (1978).Potential Psychotomimetic Antagonists. N,N-diethyl-1-methyl-3-aryl-1,2,5,6-tetrahydropyridine-5-carboxamides (Ph.D. thesis). University of Michigan.doi:10.7302/11268. Archived fromthe original on 30 March 2025.1-Hydroxymethyl LSD (25) was found to have about two-thirds the activity of LSD by Cerletti52 and Abramson,5,53 but since both 1-hydroxymethyl-LSD and 1-acetyl-LSD "are very easily hydrolyzed under alkaline conditions,"62 the high potency of these compounds might be a result of their in vivo hydrolysis to the active LSD. [...] Table 1. Human psychotomimetic potencies of LSD analogs. [...]
  7. ^Rutschmann J, Stadler PA (1978). "Chemical Background".Ergot Alkaloids and Related Compounds. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 29–85.doi:10.1007/978-3-642-66775-6_2.ISBN 978-3-642-66777-0.
  8. ^Abramson HA (1968)."Derivatives of d-Lysergic Acid and Model Psychoses". In Rupp C (ed.).Mind as a Tissue: Proceedings of the Fifth International Research Conference Held at the Lankenau Hospital, Philadelphia, Pennsylvania. New York: Harper and Row. pp. 134–169.OCLC 442122. Archived fromthe original on 30 March 2025.
  9. ^Abramson HA (March 1965). "Lysergic acid diethyl amide (LSD-25): XXXVII. Antiserotonin action of lysergic acid derivatives in allergy and neuropsychiatry".The Journal of Asthma Research.2 (3):257–262.doi:10.3109/02770906509107712.PMID 14285481.
  10. ^Konzett H, Cerletti A (1956)."Spezifische Hemmung von 5-Oxytryptamin-Effekten durch Lysergsäurediäthylamid und ähnliche Körper" [Specific inhibition of serotonin effects by lysergic acid diethylamide and similar compounds].Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie (in German).228 (1–2).doi:10.1007/BF00259761.ISSN 0028-1298. Retrieved5 June 2025.
  11. ^abcNichols DE, Oberlender R, McKenna DJ (1991)."Stereochemical Aspects of Hallucinogenesis". In Watson RR (ed.).Biochemistry and Physiology of Substance Abuse. Vol. 3. Boca Raton, Fla.: CRC Press. pp. 1–39.ISBN 978-0-8493-4463-3.OCLC 26748320.The 1-hydroxymethyl derivative was estimated to be 66% as potent as LSD, and it also serves as a metabolic intermediate in the demethylation of 1-methyl LSD, which itself is about 1/3 as active as LSD.160,193
  12. ^Rothlin E (March 1957). "Lysergic acid diethylamide and related substances".Annals of the New York Academy of Sciences.66 (3):668–676.Bibcode:1957NYASA..66..668R.doi:10.1111/j.1749-6632.1957.tb40756.x.PMID 13425249.
  13. ^Rothlin E (September 1957). "Pharmacology of lysergic acid diethylamide and some of its related compounds".The Journal of Pharmacy and Pharmacology.9 (9):569–587.doi:10.1111/j.2042-7158.1957.tb12312.x.PMID 13463749.
  14. ^Cerletti A (1959)."Comparison of Abnormal Behavioral States Induced by Psychotropic Drugs in Animals and Man". In Bradley PB, Deniker P, Radouco-Thomas C (eds.).Proceedings of the 1st International Congress of Neuro-Psychopharmacology, Rome, September 1958. Amsterdam: Elsevier. pp. 117–123. Archived fromthe original on 30 March 2025.
  15. ^Kumbar M, Sankar DV (July 1973)."Quantum chemical studies on drug actions. 3. Correlation of hallucinogenic and anti-serotonin activity of lysergic acid derivatives with quantum chemical data".Research Communications in Chemical Pathology and Pharmacology.6 (1):65–100.PMID 4734018. Archived fromthe original on 29 March 2025.Table I: Structure and Several Biological Activities of Lysergates [...]
  16. ^Sankar DV, Kumbar M (February 1974)."Quantum chemical studies on drug actions. IV. Correlation of substituent structures and anti-serotonin activity in lysergamide series".Research Communications in Chemical Pathology and Pharmacology.7 (2):259–274.PMID 4818373. Archived fromthe original on 29 March 2025.Table I: Quantum Chemical Data on Lysergamide Derivatives [...]
  17. ^Gupta SP, Singh P, Bindal MC (1 December 1983)."QSAR studies on hallucinogens".Chemical Reviews.83 (6):633–649.doi:10.1021/cr00058a003.ISSN 0009-2665.TABLE XII. Antiserotonin and Hallucinogenic Activities and Hückel's Total MO Energy of LSD and its Analogues [...]

External links

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